Author's response to reviews Title: High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo. Authors:
نویسندگان
چکیده
Annika Lehmann ([email protected]) Carsten Denkert ([email protected]) Jan Budczies ([email protected]) Ann-Christin Buckendahl ([email protected]) Silvia Darb-Esfahani ([email protected]) Aurelia Noske ([email protected]) Berit Maria Müller ([email protected]) Marcus Bahra ([email protected]) Peter Neuhaus ([email protected]) Manfred Dietel ([email protected]) Glen Kristiansen ([email protected]) Wilko Weichert ([email protected])
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HDAC Inhibitors and Heat Shock Proteins (Hsps)
Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...
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